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I designed my own 16-Bit Computer in Microsoft Excel without using Visual Basic scripts, plugins, or anything other than plain Excel. This system on a spreadsheet is based off of a custom Instruction Set Architecture that has a total of 23 instruction mnemonics and 26 opcodes. 

The main design of the CPU is broken into a fetch unit, control unit, arithmetic logic unit, register file, PC unit, several multiplexers, a memory control unit, a 128KB RAM table, and a 128x128 16-color display. 

Try it out down below:
https://github.com/InkboxSoftware/excelCPU

This video was sponsored by Brilliant
computer chip by MITHUN T M from Noun Project
Memory by Alvida from Noun project
Calculator by Uswa KDT from Noun Project